ISSP - The institute for Solid State Physics

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Inoue Group
Associate Professor

Research Associate
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Most living organisms use sun-light as energy source for their biological activity and information source to recognize environmental change. In this photobiological events, a wide variety of photo-receptive proteins play central role. Our research aims unified understanding of the mechanism of biomolecular function of various photoreceptive membrane proteins. The chemical elementary process of supra complex photoreceptive protein is studied by laser time-resolved spectroscopy and vibrational spectroscopy, and we are promoting further research by combining biochemical technique to achieve multi-layer understanding from atomic and molecular to cellar and individual level. Furthermore, whereas we are developing novel artificial biomolecules on the basis of the fundamental insights for the application to optogenetics and so on, exploration study of new photobiological phenomena and related molecular groups is conducted with big data accompanying the development of genome analysis in recent years.

Microbial rhodopsin with a variety of functions (upper) and the purified-protein samples (lower).
Transient absorption measurement of microbial rhodopsin by a nano-second pulsed laser (upper) and photo-isomerization process of retinal in rhodopsin (lower).

Research Subjects

  1. Functional and spectroscopic study on the mechanism of molecular function of photoreceptive membrane protein, rhodopsins
  2. Application of advanced spectroscopic measurement method for biomolecular study
  3. Exploration of novel photoreceptive proteins through use of genome big data
  4. Machine-learning study on the determining factor for the function of biological molecules and its application for the development of novel functional molecules