ISSP - The institute for Solid State Physics

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Noguchi Group
Associate Professor
NOGUCHI,
Hiroshi

Research Associate
HIGHCHI,
Yuji

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We study soft-matter physics and biophysics theoretically and numerically. Our main target is the physics of biomembrane and cells under various conditions. We develop membrane models and hydrodynamics simulation methods. We found the shape transitions of red blood cells and lipid vesicles in shear and capillary flows using mesoscale hydrodynamic simulations: discocyte-to-parachute, stomatocyte-to-prolate, and prolate-to-discocyte, etc. We also clarify the several fusion and fission pathways of the membrane using coarse-grained molecular simulations. In particular, the pathway via pore opening on the edge of stalk-like connection was newly found by us, and later supported by an experiment.

Snapshots of high-genus vesicles.
Sequential snapshots of membrane tubulation induced by banana-shaped protein rods.

Research Subjects

  1. Shape transformation of cells and lipid vesicles
  2. Fusion and fission of biomembranes
  3. Dynamics of membranes out of equilibrium