The chemistry of metal-organic frameworks has experienced an almost unparalleled growth in the past two decades driven by their rich functions cover a wide range and potential industry applications as high-capacity adsorbents. The talk will introduce different ways to rationally modify the structure and function of a MOF with established structure through three main parts: (1) Some interesting MOFs exhibits good stability, high loading and quick uptake of iodine. After iodine inclusion, the resulting guest changed MOFs process fascinating properties in conductivity and nonlinear optical properties. (2) Tandem post-synthetic reactions were applied to well modify the structure of precursor MOFs, leading either entirety or surface modification as well as great changes in sorption and magnetic behaviors. (3) A sequential perturbative approach to unrestraint metal coordinative environment in MOF crystals was built and thus enabling the glass formation under mild condition and reticular tuning of glass properties. The new strategies would provide useful guidelines for screening functional glass from the abundant databases of MOFs, which may open an area of research with fundamental and applied importance.