Discovery of “Heliorhodopsin”, a novel type of photo-receptive membrane protein – A new light utilization strategy of living organisms –
Nagoya Institute of Technology
The University of TokyoJapan Science and Technology Agency (JST)
A research group discovered a novel type of photo-receptive membrane protein, rhodopsin, and it was named “Heliorhodopsin”. This research was achieved by the international collaborative group of Professor Hideki Kandori, Associate Professor Keiichi Inoue (Present at the Institute for Solid State Physics, the University of Tokyo), Research Associate Professor Satoshi P. Tsunoda at OptoBio Technology Research Center, Nagoya Institute of Technology, and Professor Oded Béjà at Technion Israel Institute of Technology, Israel.
The research revealed that the amino-acid sequence of this new rhodopsin is highly different from that of type-1 and type-2 rhodopsins which were derived from micro-organisms and animals, respectively. Despite of this large differences of the sequence, it was found that heliorhodopsin binds the same type of retinal molecule as type-1 rhodopsin and shows similar photoreaction process involving retinal-isomerization and proton transfer reaction upon light illumination (Figure).
The discovery of heliorhodopsin proved the presence of a new photobiological strategy using sun-light by the living organisms on the Earth and it is expected to lead developments of new optogenetics in the future.
The research paper was published in the Nature online (June 20, 2018).
- Journal：Nature (June 20, 2018)
- Title：A distinct abundant group of microbial rhodopsins discovered using functional metagenomics
- Authors：Alina Pushkarev, Keiichi Inoue, Shirley Larom, José Flores-Uribe, Manish Singh, Masae Konno, Sahoko Tomida, Shota Ito, Ryoko Nakamura, Satoshi P. Tsunoda, Alon Philosof, Itai Sharon, Natalya Yutin, Eugene V. Koonin, Hideki Kandori*, Oded Béjà*